Helicobacter pylori infection is correlated with the incidence of erosive oral lichen planus and the alteration of the oral microbiome composition

Abstract Background Oral lichen planus (OLP), a common clinical oral disease, is associated with an increased risk of malignant transformation. The mechanism underlying the pathogenesis OLP unknown. dysbacteriosis reported to be one aetiological factors OLP. Although Helicobacter pylori infection various diseases, correlation between H. and unclear. This study aimed investigate effect on microbiome composition in Chinese population, which has high incidence infection. Result In this study, saliva samples 30 patients (OLP group) 21 negative controls (NC were collected. was detected using carbon-13-labeled urea breath test (UBT). divided into following four groups based status: -positive (OLP+), NC (NC+), -negative (OLP?), (NC?). compositions significantly different OLP? OLP+ groups. Compared those group, group had higher erosive levels salivary cytokines. contrast, cytokine not NC? NC+ Conclusions first report demonstrate that correlated